CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes

CD19-Regulated Signaling Thresholds Control Peripheral Tolerance and Autoantibody Production in B Lymphocytes

The CD19 cell surface molecule regulates signal transduction events critical for B lymphocyte development and humoral immunity. Increasing the density of CD19 expression renders B lymphocytes hyper-responsive to transmembrane signals, and transgenic mice that overexpress CD19 have increased levels of autoantibodies. The role of CD19 in tolerance regulation and autoantibody generation was theref...

Precursors of Murine B Lymphocytes

The precursors of B lymphocytes have previously been distinguished and characterized by various parameters including their ability to generate B cells after adoptive transfer, expression of surface markers a n d / o r B cell function after short-term induction in vitro, and their synthesis but not surface display o f immunoglobu l in (Ig) heavy chains (1-19). The extent to which these cells are...

Cd19-dependent activation of Akt kinase in B-lymphocytes.

CD19 is rapidly phosphorylated upon B-cell antigen receptor (BCR) cross-linking, leading to the recruitment of downstream signaling intermediates. A prominent feature of CD19 signaling is the binding and activation of phosphoinositide 3-kinase (P13K), which accounts for the majority of PI3K activity induced by BCR ligation. Recent findings have implicated activation of the serine/threonine kina...

CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.

Lipopolysaccharide (LPS) is a major gram-negative bacterial component that stimulates innate immune response and also induces B-lymphocyte activation. Recent studies have revealed that common molecular patterns of microorganisms such as LPS are recognized by toll-like receptors (TLRs). B cells have 2 known TLRs that mediate LPS signaling, TLR4 and RP105 (CD180). While TLR4 is expressed on immun...

Murine Splenic B Cell CR 3